• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    1. A method for the preparation of solid drug forms by applying the active substance to a carrier, characterized in that. in order to improve the accuracy of dosing, the dissolved or suspended substance in the form of droplets weighing 0.0001-10 mg is applied onto a flat carrier, the application of the active substance being carried out using a piezoelectric or electrostatic method. 2. Method POP1, which is also distinguished by the fact that the dissolved or suspended active substance is applied on a flat carrier of the substance in the desired geometrical order. 3. Method according to paragraphs. 1 and 2, that is, the fact that the dissolved or suspended active agent is mixed with the dye and applied to the carrier to form a code or signatures. WITH
    公开号:SU1017160A3
    申请号:SU792841757
    申请日:1979-11-14
    公开日:1983-05-07
    发明作者:Восс Гунтер；Грубер Петер
    申请人:Др.Карл Томэ Гмбх (Фирма)；
    IPC主号:
    专利说明:


    o The invention relates to medicine c1 specifically to pharmacology, to methods for dispensing active substances onto a carrier. A known method of obtaining solid dosage forms by applying the active substance to carrier 1. However, the known method does not provide accurate dosing of the active substance, since its amount is very small relative to the rest of the tablet and it is impossible to obtain a uniform distribution of the active substance on the carrier. The purpose of the invention is to improve the dosing accuracy. The goal is achieved by the fact that in the process of obtaining solid medicinal; Forms by depositing the active substance on a carrier, the dissolved or suspended active substance in the form of droplets weighing 0.0001-10 mg is applied onto a flat carrier, and the application of the active substance is carried out using a piezoelectric or electrostatic method. The distinctive feature is that the dissolved or suspended active substance is applied to a flat carrier in a desired geometric order. In addition, the dissolved or suspended active substance is mixed with the dye and applied to the carrier to form a code or label. The method is carried out in the following manner. Accurate dosing of the active substance to the carrier is achieved by the fact that a liquid, dissolved or suspended active substance is applied in a specific amount in the form of droplets weighing 0.0001-10 mg per carrier. These drops are obtained, for example, by the autoclave method, while the liquid or suspension is high. pressure is extruded through one or more narrow nozzles. After leaving the nozzle, the liquid is divided into small uniform drop with the help of piezo-vibrators. Due to the properties of the piezo-vibrator under the application of an electric field to undergo elastic deformation, a shock wave directed to the fluid is created in the tubular piezo vibrators. The increase in pressure associated with this leads to the ejection of a small amount of active substance. In the form of a petal from the outlet of the nozzle, and these petals of the liquid take a spherical shape after the release. The diameter of the outlet is, for example, 0.1 mm, and the diameter of the channel in its middle part is 1 mm. Electroconductive layers are used as electrodes for creating an electric field, for example silver layers on the lateral surface of a tubular piezoelectric vibrator. Each outlet is directed to a specific area of the carrier of the drug and causes a certain number of drops of a given volume of dissolved or suspended active substance. Depending on the adjustment of the operation of the piezovibrator, the frequency of the droplets is from 1 to 50,000 drops per second, preferably about 3000 drops / sec. Immediately after leaving the outlet openings, electrostatic or piezoelectric droplets are applied to the desired points of the drug carrier, and the drops are charged to the carrier by applying an electrical voltage. The uniformity of application of the active substance is achieved by the fact that the active substance comes from only those outlet openings that are located directly above the passing surface of the carrier, which allows the active substance to be applied in the desired geometric order. If the active substance is mixed with a dye, then simultaneously with the dosing of the active substance, coding or writing is performed on the surface of the carrier. The use of tinted active substance makes it possible to control the dosing with the aid of a reading device (and, moreover, the droplets are recorded by means of an electronic counter). Example 1. Tablets, composition in mg: Lactose75 Corn starch125 Calcium phosphate 40 Soluble starch3 Magnesium stearate 4 Collodidal silicic acid 3 Total250 Tablets of the proposed composition weighing 250 mg are dropped in weight at the time of exit from the pressing chamber. About 65 mg dissolved active substance, for example, clonidine hydrochloride in a mixture of water / ethanol. When determining the active substance in 20 separate tablets ax, the deviation from the given value is iO, 5%. Example 2. Inscriptions were applied to the carrier by means of a dosing system containing 12 tubular piezovibrators. The inscription, including the name of the drug, the dosage and time
    reception, consists of 50 points (1 letter is formed by 20 points). The weight of one drop is 0.0001 mg. The concentration of the dye of the active substance is chosen so that the inscription accurately contains 0.1 mg of the active substance. The dosing system operates at a speed of 300 letters per second, the frequency of the droplets being 3000 points per second.
    Example 3. Placebo tablets (9 mm at a constant speed of 1 m / s are passed by a strong piezo-vibrator, 100 nozzle channels of which are arranged in a circle so that they evenly cover the entire surface of the tablet with drops. The dosing process lasts 1 m / s. At this time, the piezo vibrator performs 5 lifts and in total gives 5 mg of a 20% suspension of the active substance.When determining active quality on 20 separate tablets, the deviation from the amount of active substance is + 1%. For 1 hour the suspension of active substances cover 200 thousand tablets.
    Example 4. Example 1 is repeated with the difference that the active substance is applied to 250 mg tablets in the form of 10 mg droplets. With
    this deviation from the specified value is + 0.4%.
    The proposed method provides an increase in the dosage accuracy by 10 times due to the possibility of applying the active substance to the carrier in the form of droplets of the same size and weight, with the number of cale lines applied in one process can be changed by electronic regulation. The proposed method allows certain concentrations of the drug to be added to the individual areas of the flat carrier, and this concentration relative to the carrier can be changed by providing an accurate addition of the active substance that cannot be achieved in a known manner. The proposed method makes it possible to use tablets and dragees made of cheap and economical materials as carriers, for example, flat wafers, gelatinous plates or carriers from absorbing materials, thus eliminating the need for pmyaivanie, granulating, drying and pressing granulator, which provides saving machines, production space and reduces the cost of finished drugs.
    权利要求:
    Claims (3)
    [1]
    1. METHOD FOR PRODUCING SOLID MEDICINAL FORMS by applying the active substance to a carrier, characterized in that, in order to increase the dosage accuracy, the dissolved or suspended active substance in the form of drops weighing 0.0001-10 mg is applied to a flat carrier, the application of the active substance carried out by a piezoelectric or electrostatic method.
    [2]
    2. The method according to claim 1, characterized in that the dissolved or suspended active substance is applied to a flat carrier of the substance in the desired geometric order.
    [3]
    3. The method according to PP. 1 and 2, characterized in that the dissolved or suspended active substance is mixed with a dye and applied to the carrier with the formation of a code or signatures.
    类似技术:
    公开号 | 公开日 | 专利标题
    SU1017160A3|1983-05-07|Process for preparing solid medical preparations
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    EP0011269B1|1983-04-13|Method and apparatus for dotting moulding devices by means of discrete droplets of a liquid or suspended lubricant during the manufacture of moulded objects in the pharmaceutical, food or catalytic field
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    CA2084897A1|1992-01-20|A device and method for dosing a liquid product
    Neubert et al.1991|A multilayer membrane system for modelling drug penetration into skin
    FR2331343A1|1977-06-10|NEW SPIRO | QUINUCLIDINE, ITS PREPARATION PROCESS AND MEDICINAL PRODUCT CONTAINING IT
    Geraerts et al.1983|Multiple release of peptides by electrically active neurosecretory caudo-dorsal cells of Lymnaea stagnalis
    US5158804A|1992-10-27|Particle coating apparatus for small-scale processing
    US5438886A|1995-08-08|Volumetric measurement device for a dispensing container
    FR2482523A1|1981-11-20|USE OF AN INK JET PRINTING DEVICE FOR NON-CONTACT REGISTRATION OR PRINTING ON MOLDED PHARMACEUTICAL FORMS OR ON FOOD INDUSTRY TABLETS
    US6187322B1|2001-02-13|Process and a device for the production of a flat administration form comprising a preparation which contains pharmaceutical active substances
    JPS5225015A|1977-02-24|Process for preparing fine granular drugs
    MA19731A1|1983-02-25|LEVOGYRE ISOMER OF MEQUITAZINE, PROCESS FOR PREPARING SAME AND MEDICINAL PRODUCTS CONTAINING IT.
    US20050226992A1|2005-10-13|Method and apparatus for producing a uniform film on a substrate
    WO1999055455A2|1999-11-04|Device for generating freely definable libraries of elements in the form of ligand and acceptor structures for combinatorial synthesis
    BE805210A|1974-03-25|NEW IMIDAZOIYLACETIC ACID AMIDES, THEIR PREPARATION PROCESS AND MEDICINAL PRODUCTS CONTAINING THEM
    JPH03198871A|1991-08-30|Drug sheet for percataneous administration and percataneous administration means of drug
    JP2003028830A|2003-01-29|Taste distinguishing device and taste distinguishing method
    同族专利:
    公开号 | 公开日
    RO79155B|1983-09-30|
    EP0011268A1|1980-05-28|
    EP0011268B1|1982-12-29|
    CS222678B2|1983-07-29|
    DE2849494A1|1980-05-29|
    CA1144479A|1983-04-12|
    USRE31764E|1984-12-11|
    HU181977B|1983-11-28|
    ES8101883A1|1980-12-16|
    DD147203A5|1981-03-25|
    JPH0248524B2|1990-10-25|
    RO79155A|1983-10-15|
    AT2113T|1983-01-15|
    JPS55108815A|1980-08-21|
    ES485873A0|1980-12-16|
    AU530180B2|1983-07-07|
    AU5285779A|1980-05-22|
    US4322449A|1982-03-30|
    DE2964438D1|1983-02-03|
    引用文献:
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    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    DE19782849494|DE2849494A1|1978-11-15|1978-11-15|METHOD FOR THE PRODUCTION OF MEDICINAL FORMS|
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